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DailyUpdates from LeadDiscovery: Breaking Research, Development News and Pharmareports for Drug Discovery

Assessment of anti-estrogenic activity of tamoxifen in transgenic mice expressing an enhanced green fluorescent protein gene regulated by estrogen response element. (Journal article Featured on DailyUpdates-18 Dec) (Dec 19 2005 07:35 GMT)

- Biochim Biophys Acta. 2005 Nov 8; [Epub ahead of print]

DailyUpdates from LeadDiscovery: Breaking Research, Development News and Pharmareports for Drug Discovery

Efficacy of telavancin (TD-6424), a rapidly bactericidal lipoglycopeptide with multiple mechanisms of action, in a murine model of pneumonia induced by methicillin-resistant Staphylococcus aureus. (Journal article Featured on DailyUpdates-18 Dec) (Dec 19 2005 07:35 GMT)

- Antimicrob Agents Chemother. 2005 Oct;49(10):4344-6.

DailyUpdates from LeadDiscovery: Breaking Research, Development News and Pharmareports for Drug Discovery

WHO study on Prevention of REcurrences of Myocardial Infarction and StrokE (WHO-PREMISE). (Journal article Featured on DailyUpdates-18 Dec) (Dec 19 2005 07:35 GMT)

- Bull World Health Organ. 2005 Nov;83(11):820-829. Epub 2005 Nov 10.

DailyUpdates from LeadDiscovery: Breaking Research, Development News and Pharmareports for Drug Discovery

Measuring the severity of depression and remission in primary care: validation of the HAMD-7 scale. (Journal article Featured on DailyUpdates-18 Dec) (Dec 19 2005 07:35 GMT)

- CMAJ. 2005 Nov 22;173(11):1327-34.

DailyUpdates from LeadDiscovery: Breaking Research, Development News and Pharmareports for Drug Discovery

Tricyclic pharmacophore-based molecules as novel integrin alpha(v)beta(3) antagonists. Part 2: Synthesis of potent alpha(v)beta(3)/alpha(IIb)beta dual antagonists. (Journal article Featured on DailyUpdates-18 Dec) (Dec 19 2005 07:35 GMT)

- Bioorg Med Chem. 2005 Nov 22; [Epub ahead of print]

DailyUpdates from LeadDiscovery: Breaking Research, Development News and Pharmareports for Drug Discovery

Ephedrine Blocks Rat Sciatic Nerve In Vivo and Sodium Channels In Vitro. (Journal article Featured on DailyUpdates-18 Dec) (Dec 19 2005 07:35 GMT)

- Anesthesiology. 2005 Dec;103(6):1246-1252.

DailyUpdates from LeadDiscovery: Breaking Research, Development News and Pharmareports for Drug Discovery

Tricyclic pharmacophore-based molecules as novel integrin alpha(v)beta(3) antagonists. Part III: Synthesis of potent antagonists with alpha(v)beta(3)/alpha(IIb)beta dual activity and improved water solubility. (Journal article Featured on DailyUpdates-18 Dec) (Dec 19 2005 07:35 GMT)

- Bioorg Med Chem. 2005 Nov 21; [Epub ahead of print]

DailyUpdates from LeadDiscovery: Breaking Research, Development News and Pharmareports for Drug Discovery

Design, synthesis, and evaluation of 2-alkoxydihydrocinnamates as PPAR agonists. (Journal article Featured on DailyUpdates-18 Dec) (Dec 19 2005 07:35 GMT)

- Bioorg Med Chem Lett. 2005 Nov 18; [Epub ahead of print]

DailyUpdates from LeadDiscovery: Breaking Research, Development News and Pharmareports for Drug Discovery

Does Diabetes Mellitus Abolish the Beneficial Effect of Primary Coronary Angioplasty on Long-term Risk of Reinfarction After Acute ST-Segment Elevation Myocardial Infarction Compared With Fibrinolysis? (A DANAMI-2 Substudy). (Journal article Featured on DailyUpdates-18 Dec) (Dec 19 2005 07:35 GMT)

- Am J Cardiol. 2005 Dec 1;96(11):1469-75. Epub 2005 Oct 11.

DailyUpdates from LeadDiscovery: Breaking Research, Development News and Pharmareports for Drug Discovery

Bicyclic and tricyclic thiophenes as protein tyrosine phosphatase 1B inhibitors. (Journal article Featured on DailyUpdates-18 Dec) (Dec 19 2005 07:35 GMT)

- Bioorg Med Chem. 2005 Nov 19; [Epub ahead of print]

DailyUpdates from LeadDiscovery: Breaking Research, Development News and Pharmareports for Drug Discovery

Anxiety and cognition in female histidine decarboxylase knockout (Hdc(-/-)) mice. (Journal article Featured on DailyUpdates-18 Dec) (Dec 19 2005 07:35 GMT)

- Behav Brain Res. 2005 Nov 24; [Epub ahead of print]

DailyUpdates from LeadDiscovery: Breaking Research, Development News and Pharmareports for Drug Discovery

Substituted 4-hydroxyphenyl sulfonamides as pathway-selective estrogen receptor ligands.(Journal article Featured on DailyUpdates-18 Dec) (Dec 19 2005 07:35 GMT)

- Bioorg Med Chem Lett. 2005 Nov 18; [Epub ahead of print]

DailyUpdates from LeadDiscovery: Breaking Research, Development News and Pharmareports for Drug Discovery

Patient-reported outcomes of psoriasis improvement with etanercept therapy: results of a randomized phase III trial. (Journal article Featured on DailyUpdates-18 Dec) (Dec 19 2005 07:35 GMT)

- Br J Dermatol. 2005 Dec;153(6):1192-9.

DailyUpdates from LeadDiscovery: Breaking Research, Development News and Pharmareports for Drug Discovery

Tricyclic pharmacophore-based molecules as novel integrin alpha(v)beta(3) antagonists. Part 1: Design and synthesis of a lead compound exhibiting alpha(v)beta(3)/alpha(IIb)beta dual antagonistic activity. (Journal article Featured on DailyUpdates-18 Dec) (Dec 19 2005 07:35 GMT)

- Bioorg Med Chem. 2005 Nov 22; [Epub ahead of print]

DailyUpdates from LeadDiscovery: Breaking Research, Development News and Pharmareports for Drug Discovery

Administration of Intracoronary Eptifibatide During ST-Elevation Myocardial Infarction. (Journal article Featured on DailyUpdates-18 Dec) (Dec 19 2005 07:35 GMT)

- Am J Cardiol. 2005 Dec 1;96(11):1494-7. Epub 2005 Oct 17.

SourceForge.net: Project Summary: Jacson (jacson project)

Project name: Jacson (Dec 19 2005 07:34 GMT)

- Project description: Provide a plugabble and configurable alternative to UNIX tools like grep, awk, tail, head, cut, sort, uniq or even some perl based scripts in a Java environment. A bit like what Apache Ant means to good old make.

SourceForge.net: Project Summary: Jacson (jacson project)

Developers on project: 4 (Dec 19 2005 07:34 GMT)

- Project administrators: nestefan, pcs_org

SourceForge.net: Project Summary: Jacson (jacson project)

Activity percentile (last week): 98.85% (Dec 19 2005 07:34 GMT)

- Most recent daily statistics (19 Dec 2005): Ranking: 1693, Activity percentile: 98.85%,

SourceForge.net: Project Summary: Jacson (jacson project)

Downloadable files: 2057 total downloads to date (Dec 19 2005 07:34 GMT)

- Most recent daily statistics (19 Dec 2005): Download count: 0

SourceForge.net: Project Summary: Jacson (jacson project)

Mailing lists (public): 2 (Dec 19 2005 07:34 GMT)

- Public mailing lists: jacson-user, jacson-developer

SourceForge.net: Project Summary: Jacson (jacson project)

Tracker: Bugs (0 open/0 total) (Dec 19 2005 07:34 GMT)

- Tracker description: Bug Tracking System

SourceForge.net: Project Summary: Jacson (jacson project)

Tracker: Support Requests (0 open/4 total) (Dec 19 2005 07:34 GMT)

- Tracker description: Tech Support Tracking System

SourceForge.net: Project Summary: Jacson (jacson project)

Tracker: Patches (0 open/0 total) (Dec 19 2005 07:34 GMT)

- Tracker description: Patch Tracking System

SourceForge.net: Project Summary: Jacson (jacson project)

Tracker: Feature Requests (11 open/27 total) (Dec 19 2005 07:34 GMT)

- Tracker description: Feature Request Tracking System

onegoodmove

Tools (Dec 19 2005 07:34 GMT)

- Stone Tools Reveal Humans Lived in Britain 700,000 Years AgoStone tools found on the coast of Britain suggest early humans first colonized northern Europe much earlier than previously known. Ancient flints discovered in cliffs at Pakefield in eastern England show humans lived in northern Europe some 700,000 years ago, according to researchers. They say the find indicates that humans journeyed into Britain 200,000 years earlier than experts had suspected.snip"The Pakefield evidence for human activity is rock-solid," according to Wil Roebroeks, professor of archaeology at Leiden University in The Netherlands. There is a consensus in the scientific community but there are some who still have questions as noted on Saturday Night Live Click on the picture to play the video Quicktime Video 211K '17 Quicktime 7 required Saturday Night Live...

Health Shop Vitamin Supplement

Vitamin Supplement - Alternative Health: Herbs: Shopping (Dec 19 2005 07:34 GMT)

- Alternative Health: Herbs: Shopping ... Herbazon.Com offers discounts on holistic herbs and vitamins, diet aids, and weight loss supplements for body builders ...

Dog Care Tips

Pet Insurance: you should think about it (Dec 19 2005 07:34 GMT)

- Although pet insurance has been available for approximately 20 years, many pet owners have never heard of it and are surprised that such a thing would even exist. After all, insurance is for people, right? Well, if you have ever had to empty your savings account in order to pay for a pet?s surgery or if you have ever had to put a beloved pet to sleep because you couldn?t afford medical care, then you can absolutely testify to the usefulness and worth of pet insurance.

ActionForex.com

Dollar Bounces Against the Yen 12-19-05 (Dec 19 2005 07:34 GMT)

- The USD/JPY rebounded back above the 116.00 level in an unusually volatile Asian session, marked by low volumes and lack of economic news. In absence of fresh economic data, the pair traded off technical considerations with strong support at 115.50 level coming from option traders defending those barriers before rumored expiration at the New York cut of 15:00 GMT..

fashioninspired.com

Inditex Third-Quarter Profit Rises 26% on Zara, Bershka Growth  (Fashion design agencies) (Dec 19 2005 07:34 GMT)

- Inditex Third-Quarter Profit Rises 26% on Zara, Bershka Growth  Bloomberg.com - Dec 12 11:

Shopping Gift Cards

Giving cash or gift cards? Each has perks, problems (Market Watch) (Dec 19 2005 07:34 GMT)

- Giving cash or gift cards? Each has perks, problems (Market Watch)SAN FRANCISCO (MarketWatch) — It’s a fair bet many gift recipients eagerly ripping open their holiday envelopes next weekend will consider gift cards a step up from cash, but each of these convenience gifts come with its own disadvantages. Gift cards popular again, but buyer beware [...

Expert-Small-Business-Solutions.info

Small Business Tips (Dec 19 2005 07:34 GMT)

- 2003 small business microsoft server 2003 small business microsoft window server 2003 small business premium server 2003 small business premium window server 2003 small business serial window server 2003 small business server 2003 small business server limitation 2003 small business server presentation 2003 small business server upgrade 2003 small business standard oem server 2003 small [...]

MyAppleMenu

DJs Change Their Tune On Computers (Dec 19 2005 07:33 GMT)

- Built with the consumer in mind, iPods lack the sophisticated cuing, beat-matching and mixing functions that are standard on DJ gear. But their portability and tie-ins with online music stores have captured the imagination of many devotees who see the potential for the gadget to be a DJ tool. By Seth Hamblin, Washington Post

MyAppleMenu

End Near For Mac Version Of IE (Dec 19 2005 07:33 GMT)

- Microsoft will cease support for the Mac version of Internet Explorer from December 31 and stop development of the program, the company says on its website. No further security or enhancement updates will be provided. By Sam Varghese, The Age

MyAppleMenu

Apple Finds New Digs (Dec 19 2005 07:33 GMT)

- Apple net-leased the entire 30,000-foot five-story building opposite the Empire State Building. By Lois Weiss, New York Post

IRC News - Science & Space

Lift therapeutic cloning ban, review urges (Dec 19 2005 07:33 GMT)

- An independent committee reviewing Australia's cloning and human embryo research laws has recommended the Government lift the ban on therapeutic cloning for medical research. Read More... Source: ABC News: Science and Technology

Obsolete Computer Museum Helpline

Helpline Comment (34690) (Dec 19 2005 07:33 GMT)

- John, Kevin Brown (KB), has left this plane...We will always miss our own... --T

MosNews.com RSS

Russia's Tennis Star Maria Sharapova on Promotional Tour in Japan (Dec 19 2005 07:33 GMT)

- The darling of the tennis world, Maria Sharapova, will grace Japan from Dec. 20-24 for a three-city promotional blitz that will include singles matches against Japan"s top-ranked player, Ai Sugiyama.

Longevity Meme Newsletter

Longevity Meme Newsletter, December 19 2005 (Dec 19 2005 07:33 GMT)


KNOCKSTER.COM

Toshiba gigabeat MEG-F10K Digital Audio Player by Toshiba $149.99 at TigerDirect.com (Dec 19 2005 07:33 GMT)


KNOCKSTER.COM

Ipod Belkin Media Reader for iPod with Dock Connector $44.99 at TigerDirect.com (Dec 19 2005 07:33 GMT)


KNOCKSTER.COM

Magnavox 42" Widescreen Plasma HDTV by Magnavox $1799.99 at BestBuy.com (Dec 19 2005 07:33 GMT)


KNOCKSTER.COM

Free After Rebate -EPSON Stylus CX3810 Print/Scan/Copy at Zones.com (Dec 19 2005 07:33 GMT)


KNOCKSTER.COM

Barracuda Spam Firewall 300 w/ 1 Year Energize Updates Subscription $2398.99 at Zones.com (Dec 19 2005 07:33 GMT)


KNOCKSTER.COM

Video 7 New 30" LCD TV $699 at PcConnection.com (Dec 19 2005 07:33 GMT)


Realty Reality

Prevent Accidents and Injuries In Your Home - Part 1 of 3 (Dec 19 2005 07:33 GMT)


Realty Reality

IRS Extends Transition Relief to Partnerships and Pass-Thru Entities Under New Code Section (Dec 19 2005 07:33 GMT)


News: Moldova.org: Music

Ashlee Simpson felt sick during a performance in Tokyo (Dec 19 2005 07:33 GMT)

- Ashlee Simpson, the younger sister of Jessica Simpson collapsed following a performance in Tokyo. The 21-year-old singer had performed the single "Boyfriend" for MTV Japan, when she told the audience she felt sick. Then she collapsed in an elevator and was rushed by ambulance to a hospital.

onegoodmove

Links With Your Coffee - Monday (Dec 19 2005 07:32 GMT)

- 'It no longer feels a great injustice that I have to die' "Ha, ha," he says. "Now you're talking! I would be wonderful with a 100-year moratorium on literature talk, if you shut down all literature departments, close the book reviews, ban the critics. The readers should be alone with the books, and if anyone dared to say anything about them, they would be shot or imprisoned right on the spot. Yes, shot.

Acid Reflux

Acid reflux reviews - Program helps seniors navigate choices (Salt Lake Tribune) (Dec 19 2005 07:32 GMT)

- Program helps seniors navigate choices (Salt Lake Tribune)Mohammad Mahdavi In his home country of Iran, retired police colonel Mohammad Mahdavi had to pay medical expenses out-of-pocket because the government had no health plan. But since immigrating to Utah three years ago, the 67-year-old Mahdavi has been a [...]

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