25 most recent entries:
Characterization of a functional polymorphism in the 3' utr of slc6a4 and its association with drinking intensity (Nov 22 2008 04:00 GMT)
Conclusion: These findings suggest that the allelic variations of rs1042173 affect drinking intensity in alcoholics possibly by altering serotonin transporter expression levels. This provides additional support to the hypothesis that SLC6A4 polymorphisms play an important role in regulating propensity for severe drinking. (Source: Alcoholism:
Study finds link between mood disorders, self-medication (Nov 20 2008 18:06 GMT)
null (Source: Alcohol, Tobacco and Other Drugs News)
Study: insite could save canada $20 million in decade (Nov 20 2008 17:52 GMT)
null (Source: Alcohol, Tobacco and Other Drugs News)
Heavy drinkers lie to doctors about alcohol use (Nov 20 2008 17:36 GMT)
null (Source: Alcohol, Tobacco and Other Drugs News)
Alcohol in moderation, cardioprotection, and neuroprotection: epidemiological considerations and mechanistic studies (Nov 20 2008 04:00 GMT)
In contrast to many years of important research and clinical attention to the pathological effects of alcohol (ethanol) abuse, the past several decades have seen the publication of a number of peer-reviewed studies indicating the beneficial effects of light-moderate, nonbinge consumption of varied alcoholic beverages, as well as experimental demonstrations that moderate alcohol exposure can initiate typically cytoprotective mechanisms. A considerable body of epidemiology associates moderate alcohol consumption with significantly reduced risks of coronary heart disease and, albeit currently a less robust relationship, cerebrovascular (ischemic) stroke. Experimental studies with experimental rodent models and cultures (cardiac myocytes, endothelial cells) indicate that moderate alcohol expos...
Phosphatidylethanol mediates its effects on the vascular endothelial growth factor via hdl receptor in endothelial cells (Nov 20 2008 04:00 GMT)
Conclusions: High density lipoprotein particles containing PEth bind to CLA-1 receptor and thereby increase the secretion of VEGF from endothelial cells. Ethanol-induced protective effects against coronary heart disease may be explained, at least partly, by the effects of PEth-modified HDL particles on VEGF via CLA-1-mediated mechanisms in endothelial cells. (Source: Alcoholism:
The α1-adrenergic receptor antagonist, prazosin, reduces alcohol drinking in alcohol-preferring (p) rats (Nov 20 2008 04:00 GMT)
Conclusions: The results indicate that the noradrenergic system plays a role in mediating alcohol drinking in rats of the P line and suggest that prazosin[mdash]a safe, well-characterized, and well-tolerated drug[mdash]may be an effective pharmacotherapeutic agent for the treatment of alcohol use disorders. (Source: Alcoholism: Clinical and Experimental Research)
Drinking and alcohol-related harm among new zealand university students: findings from a national web-based survey (Nov 20 2008 04:00 GMT)
Conclusions: Strategies are needed to reduce the availability and promotion of alcohol on and around university campuses in New Zealand. Given the high prevalence of binge drinking in high school and its strong association with later binge drinking, strategies aimed at youth drinking are also a priority. In universities, high-risk drinkers should be identified and offered intervention early in their undergraduate careers. (Source:
Early social isolation in male long-evans rats alters both appetitive and consummatory behaviors expressed during operant ethanol self-administration (Nov 20 2008 04:00 GMT)
Discussion: The effects of postweaning social isolation on ethanol drinking in the home cage are also manifest during operant self-administration. Importantly, these alterations in adult operant self-administration are ethanol-specific. (Source: Alcoholism:
In utero ethanol exposure impairs defenses against experimental group b streptococcus in the term guinea pig lung (Nov 20 2008 04:00 GMT)
Conclusions: In utero ETOH exposure impaired the neonatal lung's defense against experimental GBS, while maintaining GSH availability protected the ETOH-exposed lung. This study suggested that fetal alcohol exposure deranges the neonatal lung's defense against bacterial infection, and support further investigations into the potential therapeutic role for exogenous GSH to augment neonatal AM function. (Source: Alcoholism:
Alcohol-induced tolerance and physical dependence in mice with ethanol insensitive α1 gabaa receptors (Nov 20 2008 04:00 GMT)
Conclusions: We conclude that [alpha]1-GABAA-Rs play a role in tolerance to ethanol-induced motor ataxia and withdrawal-related hyperexcitability. However, other aspects of behavioral tolerance and physical dependence do not rely on [alpha]1-containing GABAA-Rs. (Source: Alcoholism:
Behavioral consequences of repeated nicotine during adolescence in alcohol-preferring aa and alcohol-avoiding ana rats (Nov 20 2008 04:00 GMT)
Conclusions: These findings provide no or little support for the views that adolescent animals are more sensitive to the neurobehavioral effects of repeated exposure to nicotine and that exposure to nicotine in adolescence may contribute to enhanced vulnerability to ethanol abuse. Furthermore, genetic predisposition to high or low ethanol self-administration does not seem to be a factor that influences individual vulnerability to the neurobehavioral effects of repeated administration of nicotine. (Source: Alcoholism:
A within-group design of nontreatment seeking 5-httlpr genotyped alcohol-dependent subjects receiving ondansetron and sertraline (Nov 20 2008 04:00 GMT)
Conclusion: This study suggests that ondansetron may reduce alcohol consumption in alcohol-dependent individuals who have the L/L genotype as measured naturalistically and during the ASAE. By contrast there was no support that sertraline reduces alcohol use in individuals who have S/S or S/L genotypes. Evidence in the literature suggests that AD in some individuals may be influenced by a gene by socio-environmental interaction making pharmacological treatment with serotonergic drugs complex. Research must consider that typologies may predict successful treatment of AD in future trials.
Molecular mechanisms of alcoholic fatty liver (Nov 20 2008 04:00 GMT)
Alcoholic fatty liver is a potentially pathologic condition which can progress to steatohepatitis, fibrosis, and cirrhosis if alcohol consumption is continued. Alcohol exposure may induce fatty liver by increasing NADH/NAD+ ratio, increasing sterol regulatory element-binding protein-1 (SREBP-1) activity, decreasing peroxisome proliferator-activated receptor-[alpha] (PPAR-[alpha]) activity, and increasing complement C3 hepatic levels. Alcohol may increase SREBP-1 activity by decreasing the activities of AMP-activated protein kinase and sirtuin-1. Tumor necrosis factor-[alpha] (TNF-[alpha]) produced in response to alcohol exposure may cause fatty liver by up-regulating SREBP-1 activity, whereas betaine and pioglitazone may attenuate fatty liver by down-regulating SREBP-1 activity. PPAR-[alph...
Drinking patterns and myocardial infarction: a linear dose–response model (Nov 20 2008 04:00 GMT)
Conclusions: Use of a well-specified mathematical dose[ndash]response model provided precise estimates for the first time of how drinking frequency and dosage each contribute linearly to the overall impact of a given drinking pattern on MI risk in men and women. (Source: Alcoholism: Clinical and Experimental Research)
Availability and characteristics of nonbeverage alcohols sold in 17 russian cities in 2007 (Nov 20 2008 04:00 GMT)
Conclusions: While the 2006 federal regulations introduced in part to reduce the availability and consumption of nonbeverage alcohols may have had some effect on certain classes of nonmedicinal products, up until June 2007 at least, medicinal tinctures as well as some other nonbeverage alcohols that are consumed appear to have been readily available. (Source: Alcoholism: Clinical and Experimental Research)
Hawaii police say medical marijuana law provided a front for traffickers (Nov 19 2008 19:14 GMT)
null (Source: Alcohol, Tobacco and Other Drugs News)
Indiana legislators to pursue statewide smoke-free law (Nov 19 2008 19:08 GMT)
null (Source: Alcohol, Tobacco and Other Drugs News)
Drug violence jumps the mexican border to the u.s. (Nov 19 2008 19:02 GMT)
null (Source: Alcohol, Tobacco and Other Drugs News)
Some anesthesiologists subjected to drug tests (Nov 19 2008 18:51 GMT)
null (Source: Alcohol, Tobacco and Other Drugs News)
Gender and racial/ethnic disparities in the impact of hiv prevention programming in substance abuse treatment. (Nov 19 2008 14:25 GMT)
Conclusions: Racial/ethnic disparities exist in the capacity for HIV prevention programming offered as part of substance abuse treatment to reduce HIV-risk behavior. The findings highlight the need for the development of culturally competent service delivery strategies to enhance the impact of these services for all groups. PMID: 19016178 [PubMed - in process] (Source:
Readiness to change as a predictor of drug-related behaviors in a sample of rural felony probationers. (Nov 19 2008 14:25 GMT)
Conclusion: Readiness to change has important implications for treatment involving rural probationers. PMID: 19016179 [PubMed - in process] (Source: The American Journal of Drug and Alcohol Abuse)
Predictors of college student support for alcohol control policies and stricter enforcement strategies. (Nov 19 2008 14:25 GMT)
Conclusions: Results provide valuable insights to inform the development of media campaigns and other environmental management initiatives. PMID: 19016180 [PubMed - in process] (Source: The American Journal of Drug and Alcohol Abuse)
Dysfunction of the hypothalamic-pituitary-adrenal axis in opioid dependent subjects: effects of acute and protracted abstinence. (Nov 19 2008 14:25 GMT)
Conclusions: Our findings suggest that chronic opioid dependence may cause reduced function of the HPA axis, while opioid withdrawal may decrease the response of the pituitary to CRH and increase the adrenal response to ACTH. PMID: 19016181 [PubMed - in process] (Source: The American Journal of Drug and Alcohol Abuse)
Electrophoretic profile of serum proteins in opium and heroin dependents. (Nov 19 2008 14:25 GMT)
Conclusion: This finding may be attributed to the higher probability of infectious diseases in opioids addicts. PMID: 19016182 [PubMed - in process] (Source: The American Journal of Drug and Alcohol Abuse)
|
